## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a โFull Textโ option. The original article is trackable v
Stereospecific synthesis of 7-deoxy-6-hydroxy paclitaxel
โ Scribed by Mark D. Wittman; Thomas J. Alstadt; John F. Kadow; Dolatrai M. Vyas; Kathy Johnson; Craig Fairchild; Byron Long
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 193 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
A novel Mannich type condensation between the monomethyl ester of acetonedicarboxylic acid, methylamine hydrochloride, and hydrolyzed dimethoxydihydrothran gave 6-or 7-functionalized flketo ester tropanes 12 -15. Further elaboration afforded a series of 6-or 7-hydroxy and 6-or 7methoxy 21~-methoxyca
It is well documented 2,3,4,5 that the primary reaction in the metabolism of A'-and Al(e) -THCs\* (la and 2a) is oxidation to the 7-hydroxy derivatives J& and &.
The stereospeciยฎc synthesis of 6-a-hydroxy paclitaxel 10, the major human metabolite of paclitaxel, is described. The 6,7-a-diol 4, obtained from paclitaxel, is converted to the 6,7-b-cyclic sulfate followed by nitrate addition and reduction to aord the title compound.