✦ LIBER ✦

Synthesis of nevirapine and its major metabolite

✍ Scribed by K. G. Grozinger; V. Fuchs; K. D. Hargrave; S. Mauldin; J. Vitous; S. Campbell; J. Adams

Book ID: 112131155
Publisher: Journal of Heterocyclic Chemistry
Year: 1995
Tongue: English
Weight: 377 KB
Volume: 32
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570320144

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Synthesis of five nevirapine metabolites

✍ Karl G. Grozinger; Denis P. Byrne; Laurence J. Nummy; Michael D. Ridges; Annette 📂 Article 📅 2000 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 780 KB

## Abstract Nevirapine (**1**) is a non‐nucleoside reverse transcriptase inhibitor marketed for HIV treatment by Boehringer Ingelheim as Viramune® since 1996. __In vitro__ studies of nevirapine biotransformation using human liver microsomes demonstrated the formation of five major metabolites. This

Synthesis of labeled ambroxol and its ma

Synthesis of labeled ambroxol and its major metabolites

✍ Bachir Latli; Matt Hrapchak; Heinz-Karl Switek; Daniel M. Retz; Dhileepkumar Kri 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 253 KB

## Abstract Ambroxol is a mucolytic agent used in the treatment of respiratory diseases. Herein, we report the synthesis of carbon‐14‐labeled ambroxol with the radioactive atom(s) either on the benzylic carbon or uniformly in the cyclohexyl ring with specific activities of 59 and 81 mCi/mmol, respe

ChemInform Abstract: Synthesis of Five N

ChemInform Abstract: Synthesis of Five Nevirapine Metabolites.

✍ Karl G. Grozinger; Denis P. Byrne; Laurence J. Nummy; Michael D. Ridges; Annette 📂 Article 📅 2000 🏛 John Wiley and Sons ⚖ 35 KB

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

A short synthesis of [14C]-labelled leva

A short synthesis of [14C]-labelled levamisole and its major metabolite

✍ Cor G.M. Janssen; Jos B.A. Thijssen; Willy L.M. Verluyten 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 109 KB

## Abstract Levamisole (**I**) is the __levo__ isomer of tetramisole. It is a broad spectrum anthelmintic which is used extensively as a veterinary drug for food producing animals. Metabolism and environmental studies necessitated the synthesis of ^14^C‐labelled levamisole (**6**) and of its major

Synthesis of [14C]-labelled repinotan hy

Synthesis of [14C]-labelled repinotan hydrochloride and its major metabolite M-6

✍ D. Seidel; M. Conrad; Y. Schoof; R. Schohe-Loop 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 150 KB

## Abstract For studies of pharmacokinetics and drug metabolism of the new 5‐HT~1A~ agonist repinotan, the ^14^C‐labelled version was synthesized. Starting from [U‐^14^C]phenol, a 10‐step synthesis led to 457 mg (1.58 GBq) of [U‐^14^C]repinotan hydrochloride, labelled uniformly in the aromatic ring

A practical asymmetric synthesis of (R)-

A practical asymmetric synthesis of (R)-fluoxetine and its major metabolite (R)-norfluoxetine

✍ James W Hilborn; Zhi-Hui Lu; Alex R Jurgens; Q.Kevin Fang; Paul Byers; Stephen A 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 62 KB

A convenient and chromatography-free synthesis for the enantiomers of fluoxetine and norfluoxetine is described. The synthesis relied on the use of the CBS reduction, and Hofman rearrangement to establish the key common intermediate 5, and enrichment of optical purity of the final product by crystal