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A practical asymmetric synthesis of (R)-fluoxetine and its major metabolite (R)-norfluoxetine

✍ Scribed by James W Hilborn; Zhi-Hui Lu; Alex R Jurgens; Q.Kevin Fang; Paul Byers; Stephen A Wald; Chris H Senanayake

Book ID: 104231922
Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 62 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)01877-9

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✦ Synopsis

A convenient and chromatography-free synthesis for the enantiomers of fluoxetine and norfluoxetine is described. The synthesis relied on the use of the CBS reduction, and Hofman rearrangement to establish the key common intermediate 5, and enrichment of optical purity of the final product by crystallization as the tartrate salt.

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