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Hemodynamic and electrocardiographic effects of fluoxetine and its major metabolite, norfluoxetine, in anesthetized dogs

✍ Scribed by Mitchell I. Steinberg; Jeffrey K. Smallwood; Donald R. Holland; Frank P. Bymaster; Kerry G. Bemis

Book ID
113206863
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
869 KB
Volume
82
Category
Article
ISSN
0041-008X

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A practical asymmetric synthesis of (R)-
A practical asymmetric synthesis of (R)-fluoxetine and its major metabolite (R)-norfluoxetine
✍ James W Hilborn; Zhi-Hui Lu; Alex R Jurgens; Q.Kevin Fang; Paul Byers; Stephen A πŸ“‚ Article πŸ“… 2001 πŸ› Elsevier Science 🌐 French βš– 62 KB

A convenient and chromatography-free synthesis for the enantiomers of fluoxetine and norfluoxetine is described. The synthesis relied on the use of the CBS reduction, and Hofman rearrangement to establish the key common intermediate 5, and enrichment of optical purity of the final product by crystal