๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Synthesis of five nevirapine metabolites

โœ Scribed by Karl G. Grozinger; Denis P. Byrne; Laurence J. Nummy; Michael D. Ridges; Annette Salvagno

Publisher
Journal of Heterocyclic Chemistry
Year
2000
Tongue
English
Weight
780 KB
Volume
37
Category
Article
ISSN
0022-152X

No coin nor oath required. For personal study only.

โœฆ Synopsis

Abstract

Nevirapine (1) is a nonโ€nucleoside reverse transcriptase inhibitor marketed for HIV treatment by Boehringer Ingelheim as Viramuneยฎ since 1996. In vitro studies of nevirapine biotransformation using human liver microsomes demonstrated the formation of five major metabolites. This paper describes the syntheses of these metabolites.

๐Ÿ“œ SIMILAR VOLUMES

ChemInform Abstract: Synthesis of Five N
ChemInform Abstract: Synthesis of Five Nevirapine Metabolites.
โœ Karl G. Grozinger; Denis P. Byrne; Laurence J. Nummy; Michael D. Ridges; Annette ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons โš– 35 KB

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a โ€œFull Textโ€ option. The original article is trackable v

Synthesis of tricyclic triazepinones rel
Synthesis of tricyclic triazepinones related to nevirapine
โœ Sabrina Castellano; Giorgio Stefancich; Paolo La Colla; Chiara Musiu ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Journal of Heterocyclic Chemistry ๐ŸŒ English โš– 297 KB

## Abstract Two novel tricyclic triazepinones structurally related to the reverse transcriptase inhibitor nevirapine were prepared from __N__โ€(2โ€nitrophenyl)โ€ and __N__โ€(3โ€nitroโ€2โ€pyridinyl)โ€1__H__โ€pyrrolโ€1โ€amine. The synthetic sequence includes alkylation, reduction of the nitro group, triphosgene