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Synthesis of tricyclic triazepinones related to nevirapine

✍ Scribed by Sabrina Castellano; Giorgio Stefancich; Paolo La Colla; Chiara Musiu

Publisher
Journal of Heterocyclic Chemistry
Year
2000
Tongue
English
Weight
297 KB
Volume
37
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

Two novel tricyclic triazepinones structurally related to the reverse transcriptase inhibitor nevirapine were prepared from N‐(2‐nitrophenyl)‐ and N‐(3‐nitro‐2‐pyridinyl)‐1__H__‐pyrrol‐1‐amine. The synthetic sequence includes alkylation, reduction of the nitro group, triphosgene reaction followed by intramolecular cyclization. Activity of the two compounds against the HIV‐1 multiplication in acutely infected cells is also reported.

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