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Synthesis of the enantiomers of 3-deuterium labelled lactic acid

✍ Scribed by Michèle Sanière; Hassane El Hafa; Yves le Merrer; Jean Claude Depezay; Francis Rocchiccioli

Publisher
John Wiley and Sons
Year
1991
Tongue
French
Weight
315 KB
Volume
29
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Both R‐ and S‐ enantiomers of 3‐monodeuterated lactic acid ([3‐^2^H]‐2(R) and 2(S)‐hydroxypropanoic acids) were synthesized by regiospecific nucleophilic opening of diastereoisomer epoxides derived from D‐mannitol, with lithium aluminium deuteride. Spectroscopic analysis of the product shows a complete deutero‐incorporation which makes [3‐^2^H]‐lactic acid suitable as an internal standard using gas chromatography‐mass spectroscopy.

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