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Synthesis of deuterium labeled 1,3-dimethyluric acid

✍ Scribed by Kumiko Mamada; Takashi Furuta; Yasuji Kasuya

Publisher
John Wiley and Sons
Year
1987
Tongue
French
Weight
334 KB
Volume
24
Category
Article
ISSN
0022-2135

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✦ Synopsis

A synthetic procedure for l13-di(trideuteromethyl)uric acid is described. Deuterium labeling of the N-1 and N-3 positions w a s achieved by methylation of 4-amino-5carbethoxyuracil with di( trideuteromethy1)-sulfate followed by cyclization of the dimethylated intermediate by heating. The synthesis resulted in a product with 99.4% d isotopic purity, which is selectively deuterated in the methy% groups at the N-1 and N -3 positions and chemically pure.

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