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Synthesis of deuterium-labeled pregabalin

✍ Scribed by Zucheng Shen; Wenchao Wu; Wei Wang; Liqin Chen

Publisher
John Wiley and Sons
Year
2011
Tongue
French
Weight
150 KB
Volume
54
Category
Article
ISSN
0022-2135

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✦ Synopsis

This paper describes the synthesis of deuterium‐labeled pregabalin. The stable isotopic‐labeled compound was obtained in nine steps starting from the commercially available 4‐[^2^H~11~]methylvaleric acid as the stable‐labeled reagent. It is used as an internal standard for analysis and metabolic studies.

Pregabalin labeled with ^2^H was obtained in nine steps using the commercially available 4‐[^2^H~11~]methylvaleric acid as the stable‐labeled reagent. The synthesis prevents deuterium from scrambling and offers the labeled compound with over 99% isotopic enrichment. Copyright © 2011 John Wiley & Sons, Ltd.

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