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Synthesis of deuterium-labeled nitrosomethylethylamines

✍ Scribed by Mario M. Mangino; William Lijinsky; George M. Singer

Publisher
John Wiley and Sons
Year
1978
Tongue
French
Weight
270 KB
Volume
14
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Ethyl isocyanate, N‐methylacetamide, N‐methylacetamide‐d3, and N‐methylacetamide‐d6 were reduced with lithium aluminum deuteride and then nitrosated with sodium nitrite to yield, respectively, nitrosomethyl (‐__d__3) ethylamine, nitrosomethylethyl (α‐d2) amine, nitrosomethylethyl (‐__d__5) amine, and nitrosomethyl (‐__d__3) ethyl (__d__5) amine. The characterization of the compounds by mass spectrometry is described.

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