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Synthesis of the C(11)–C(20) segment of the cytotoxic macrolide epothiline B

✍ Scribed by Johann Mulzer; Andreas Mantoulidis; Elisabeth Öhler

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
185 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

Compound 11, representing the C(I 1)-C(20) segment of the macrolide epothilone B (lb) has been prepared using two Wittig reactions and a Sharpless asymmetric epoxidation as the key steps.

📜 SIMILAR VOLUMES

Synthesis of the C(1)-C(9) segment of th
Synthesis of the C(1)-C(9) segment of the cytotoxic macrolides epothilon A and B
✍ Johann Mulzer; Andreas Mantoulidis 📂 Article 📅 1996 🏛 Elsevier Science 🌐 French ⚖ 213 KB

The C( 1)-C(9) segment 3 of the macrolides epothilon A and B 1, two new cytotoxic natural products, has been synthesized in a direct manner. Key steps in the synthesis are a stereoselective aldol reaction of 6 and 7 and a Brown allylation of 9.