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Asymmetric synthesis of the C(17)–(20) segment of the antineoplastic macrolide bryostatin 1

✍ Scribed by Karl J. Hale; J.A. Lennon; Soraya Manaviazar; Muhammad H. Javaid; Christopher J. Hobbs


Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
238 KB
Volume
36
Category
Article
ISSN
0040-4039

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Compound 11, representing the C(I 1)-C(20) segment of the macrolide epothilone B (lb) has been prepared using two Wittig reactions and a Sharpless asymmetric epoxidation as the key steps.