Synthetic studies on bryostatins, potent antineoplastic agents: Synthesis of the C17C27 fragment of C20 oxygenated bryostatins
✍ Scribed by Ken Ohmori; Shigeru Nishiyama; Shosuke Yamamura
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 273 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
R)-Carvone is a suitable chiral template for the synthesis of differently protected (4S,6R,7R)-trihydroxy-l-octyne derivatives, the C27-C34 fragment of bryostatins. Also other potentially interesting chiral building blocks are described.
The C28-C32 cyclohexyl group of the natural product, FK-506, was prepared enantioselectively from the iodolactor~ by replacement of iodide with retention of configuration. The C27-C28 trisubstituted olefin was introduced stereoselectively via a classical aldol/elimination sequence employing titanium