𝔖 Bobbio Scriptorium
✦   LIBER   ✦

ChemInform Abstract: Synthesis of the C(11)—C(20) Segment of the Cytotoxic Macrolide Epothilone B.

✍ Scribed by J. MULZER; A. MANTOULIDIS; E. OEHLER

Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
29
Category
Article
ISSN
0931-7597

No coin nor oath required. For personal study only.

✦ Synopsis

Synthesis of the C(11)-C(20) Segment of the Cytotoxic Macrolide Epothilone B.

-The fragment (VIII) is synthesized from (S)-malic acid (I) via 2 Wittig reactions and a Sharpless asymmetric epoxidation. -

📜 SIMILAR VOLUMES

ChemInform Abstract: Chiral Synthesis of
ChemInform Abstract: Chiral Synthesis of the C3-13 Segment of Epothilone A.
✍ Z.-Y. LIU; C.-Z. YU; J.-D. YANG 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB

Chiral Synthesis of the C 3-13 Segment of Epothilone A. -Epothilones represent a new class of macrolides showing all the biological effects of taxol, but their structure is totally different. On route to an epothilone A synthesis, the preparation of the C 3 -C 13 segment (V) from inexpensive gerani