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Synthesis of the anti-tumor agent CI-973 {[SP-4-3-(R)]-[1,1-cyclobutanedicarboxylato(2)](2-methyl-1,4-[4-14C]butanediamine-N,N′)platinum}

✍ Scribed by I. Victor Ekhato; James D. Hoeschele; Che C. Huang; Bela Nanavaty; Helen T. Lee

Publisher
John Wiley and Sons
Year
1993
Tongue
French
Weight
307 KB
Volume
33
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Starting from the chiral compound 1, (R)‐(+)‐2‐methyl‐1,4‐[^14^C]butanediamine 7 was synthesized in a sequence of reactions in which ^14^C‐label was introduce using label potassium cyanide. Compound 7 was reacted with potassium tetraiodoplatinate and silver 1,1‐cyclobutanedicarboxylate to make the title compound {[SP‐4‐3‐(R)]‐1,1‐cyclobutanedicarboxylato(2)platinum} 11.

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