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Synthesis of tetrazole-13C and 1,2,4-triazole-1,2-15N2

✍ Scribed by Roger S. Rowlett; Thomas Klysa; William W. Shiraki

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
141 KB
Volume
28
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

We report here the syntheses of tetrazole‐^13^C and 1,2,4‐triazole‐1,2‐^15^N~2~ by simple, one‐step procedures using common, commercially available, isotopically‐labeled starting materials. tetrazole‐ ^13^C is conveniently prepared from K^13^CN and NaN~3~ in 70% yield, almost twice the best reported yield for (unlabeled) tetrazole by similar synthetic methods. 1,2,4‐triazole‐1,2‐^15^N~2~ was synthesized in 35% yield from hydrazine‐^15^N~2~ sulfate and 1,3,5‐triazine. From ^15^N‐NMR we determined that ^15^N was specifically incorporated into the 1 and 2 positions of the triazole ring.

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