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Synthesis of [13C4,15N2]pyrrolo[2,1-f][1,2,4]triazinone

✍ Scribed by Marc D. Ogan; Scott Bach Tran; J. Kent Rinehart

Publisher
John Wiley and Sons
Year
2006
Tongue
French
Weight
110 KB
Volume
49
Category
Article
ISSN
0022-2135

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✦ Synopsis

13

C 4 , 15 N 2 ]Pyrrolotriazinone, 1, was synthesized in six steps from ethyl (1,2,3,4-13 C 4 )acetoacetate and ( 15 N)ammonium hydroxide. A total of 1.3 g [ 13 C 4 , 15 N 2 ]pyrrolotriazinone was obtained in an overall yield of 17% based on isotopic ethyl acetoacetate. Chemical purity was determined by HPLC to be 99.5%. The percent [ 13 C, 15 N]-isotopic abundance in [ 13 C 4 , 15 N 2 ]pyrrolotriazinone was determined by mass spectral analysis to be 98.0%. The fully assigned 1 H and 13 C NMR spectra of [ 13 C 4 , 15 N 2 ]pyrrolotriazinone were consistent with the desired structure.

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