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Synthesis of Tetrasubstituted α-Aminophosphonic Acid Derivatives from Trisubstituted α-Aminophosphonates

✍ Scribed by Vicario, Javier; Ortiz, Pablo; Palacios, Francisco


Book ID
125425410
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
327 KB
Volume
2013
Category
Article
ISSN
1434-193X

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Chiral ␣-aminophosphonic acid derivatives are efficiently synthesized by asymmetric hydrogenation of the prochiral N-acyl-␣,␤-dehydroaminophosphonates. PROPRAPHOS-Rh-catalysts from readily available (S)-and (R)-Propranolol proved to be suitable in the homogenous reaction affording an enantiomeric ex