𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Enantioselective synthesis of α-aminophosphonic acid derivatives by hydrogenation

✍ Scribed by Ute Schmidt; Hans Walter Krause; Günther Oehme; Manfred Michalik; Christine Fischer

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
208 KB
Volume
10
Category
Article
ISSN
0899-0042

No coin nor oath required. For personal study only.

✦ Synopsis

Chiral ␣-aminophosphonic acid derivatives are efficiently synthesized by asymmetric hydrogenation of the prochiral N-acyl-␣,␤-dehydroaminophosphonates. PROPRAPHOS-Rh-catalysts from readily available (S)-and (R)-Propranolol proved to be suitable in the homogenous reaction affording an enantiomeric excess of 87-92% with high rate. The aminophosphonic acid derivatives and precursors were fully characterized by 1

📜 SIMILAR VOLUMES

ChemInform Abstract: Synthesis of α-Subs
ChemInform Abstract: Synthesis of α-Substituted α-Aminophosphinic and α- Aminophosphonic Acids.
✍ T. I. OSIPOVA; A. V. BELYANKIN; A. R. KHOMUTOV; YU. N. ZHUKOV; E. N. KHURS; R. M 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB

Synthesis of α-Substituted α-Aminophosphinic and α-Aminophosphonic Acids. -The reaction of ketoximes (I) with hypophosphorous acid affords previously unknown phosphinic acids (II), which are smoothly oxidized into the corresponding phosphonic acids (III). -(OSIPOVA, T. I.;

Synthesis of cyclic esters of N-toluenes
Synthesis of cyclic esters of N-toluenesulfonyl α-aminophosphonic acid
✍ Qing Dai; Hua Wo; Ruyu Chen 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 264 KB

Many new cyclic esters of N-toluenesulfonyl ␣-aminophosphonic acids were synthesized by the three-component reaction of p-toluenesulfonamide, an aromatic aldehyde, and 2-chloro-1,3,2-benzodioxaphosphole in anhydrous benzene. Different reaction conditions have been investigated, and the related react

Highly Enantioselective Transfer Hydroge
Highly Enantioselective Transfer Hydrogenation of α-Imino Esters by a Phosphoric Acid
✍ Qiang Kang; Zhuo-An Zhao; Shu-Li You 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 77 KB

## Abstract Chiral phosphoric acids have been identified as highly efficient organocatalysts for the asymmetric transfer hydrogenation of α‐imino esters and amide. Utilizing Hantzsch esters as the hydrogen donor, versatile highly enantioenriched α‐amino esters and their derivatives were obtained wi