Synthesis of α-Substituted α-Aminophosphinic and α-Aminophosphonic Acids. -The reaction of ketoximes (I) with hypophosphorous acid affords previously unknown phosphinic acids (II), which are smoothly oxidized into the corresponding phosphonic acids (III). -(OSIPOVA, T. I.;
✦ LIBER ✦
ChemInform Abstract: Stereoselective Synthesis of α-Aminophosphonic Acids and Derivatives.
✍ Scribed by Mario Ordonez; Haydee Rojas-Cabrera; Carlos Cativiela
- Publisher
- John Wiley and Sons
- Year
- 2009
- Weight
- 17 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0931-7597
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Chiral ␣-aminophosphonic acid derivatives are efficiently synthesized by asymmetric hydrogenation of the prochiral N-acyl-␣,-dehydroaminophosphonates. PROPRAPHOS-Rh-catalysts from readily available (S)-and (R)-Propranolol proved to be suitable in the homogenous reaction affording an enantiomeric ex