New conformationally restricted glutamate analogues 2-(3'-alkyl-2'-carboxycyclopropyl)glycines (la-e and 2a-e) were enantioselectively prepared by the addition-elimination reaction of the chiral lithium bislactim ether anion of 3 to racemic 4-alkyl-4-bromobut-2-enoates.
Synthesis of tert-Alkyl-Substituted Glycines
✍ Scribed by Prof. Dr. Ulrich Schöllkopf; Dipl.-Chem. Rolf Meyer
- Publisher
- John Wiley and Sons
- Year
- 1975
- Tongue
- English
- Weight
- 358 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0044-8249
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✦ Synopsis
Communications are brief preliminary reports of research work in all areas of chemistry which, on account of its fundamental significance, novelty, or general applicability, should be of interest to a broad spectrum of chemists. Authors of communications are requested to state reasons of this kind justlfying publication on submission of their manuscript. The same reasons should be clearly apparent from the manuscript. In cases where the editorial staff decide, after due consultation with independent referees, that these conditions are not met, manuscripts will bereturned to theauthors with the request to submit them for publication in a specialist journal catering for scientists working in the field concerned.
📜 SIMILAR VOLUMES
Optically active a-indolyl N-substituted glycines were synthesized by reaction of an indolyl boronic acid with glyoxylic acid using chiral methylbenzylamine as the chiral auxiliary with high diastereoselectivity. The absolute configuration of the product was determined by a single-crystal X-ray anal
## Abstract __tert__‐ Alkyl sulfides are conveniently prepared from α‐(1__H__‐benzotriazol‐1‐yl)alkyl sulfides by displacement of the 1__H__‐benzotriazol‐1‐yl group with __Grignard__ reagents. The 1‐[α‐(alkylthio)alkyl]‐ and 1‐[α‐(arylthio)alkyl]‐1__H__‐benzotriazole intermediates are easily availa