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Enantioselective synthesis of 2-(3′-alkyl-2′-carboxy cyclopropyl)glycines

✍ Scribed by Angel Mazón; Concepción Pedregal; William Prowse

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 476 KB
Volume: 55
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(99)00333-6

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✦ Synopsis

New conformationally restricted glutamate analogues 2-(3'-alkyl-2'-carboxycyclopropyl)glycines (la-e and 2a-e) were enantioselectively prepared by the addition-elimination reaction of the chiral lithium bislactim ether anion of 3 to racemic 4-alkyl-4-bromobut-2-enoates.

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