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Synthesis of substituted anilino-(3-methoxy-4-substituted acetoxy) benzylidenes and their monoamine oxidase inhibitory and anticonvulsant properties

✍ Scribed by Shiva P. Singh; Anshumali Chaudhari; Virgil I. Stenberg; Surendra S. Parmar

Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
367 KB
Volume
65
Category
Article
ISSN
0022-3549

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✦ Synopsis

Several substituted anilino-(3-methoxy-4-substituted acet0xy)benzylidenes were synthesized and characterized by their sharp melting points and elemental analyses. All substituted benzylidenes competitively inhibited the in uitro monoamine oxidase activity of rat brain homogenates and possessed anticonvulsant activity against pentylenetetrazol-induced convulsions in mice.

Keyphrases Benzylidenes, substituted-synthesized, screened for effect on monoamine oxidase activity and anticonvulsant properties Monoamine oxidase activity-effect of various substituted anilinobenzylidenes, rat brain homogenate 0 Anticonvulsant activity-various substituted anilinobenzylidenes screened, mice Structure-activity relationships-various substituted anilinobenzylidenes synthesized and screened for effect on monoamine oxidase activity and anticonvulsant properties

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modates only about three cupric ions, which are relatively tightly bound, while the other accommodates about 16 cupric ions, which are rather weakly bound. It is possible that the first three cupric ions bind intimately by penetrating the protein while the rest of the cupric ions bind weakly to the