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Synthesis of substituted 1-norbornylamines with antiviral activity.

✍ Scribed by Garcia Martinez, A.; Teso Vilar, E.; Garcia Fraile, A.; de la Cerero, S.; Rodriguez Herrero, M. E.; Martinez Ruiz, P.; Subramanian, L. R.; Garcia Gancedo, A.

Book ID
123613051
Publisher
American Chemical Society
Year
1995
Tongue
English
Weight
530 KB
Volume
38
Category
Article
ISSN
0022-2623

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A series of new quinoline substituted oxiranes were synthesised by the reaction of 2-N-(chloroacetyl)-1-(4'-methyl -2'-quinolinyl) hydrazide and aromatic aldehydes. These compounds were tested against encephalomyocarditis virus (EMCV) and only two compounds exhibited protection against the virus.