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Synthesis of some N-methyl-1,2,3,4-tetrahydroisoquinolines by Friedel–Crafts cyclisation using benzotriazole auxiliary

✍ Scribed by Locher, Cornelia; Peerzada, Naseem


Book ID
121411398
Publisher
Royal Society of Chemistry
Year
1999
Weight
167 KB
Volume
2
Category
Article
ISSN
1472-7781

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## Abstract The synthesis of __N__‐methyl‐4‐pyridyl‐1,2,3,4‐tetrahydroisoquinolines **(6a,b,c)** was achieved __via__ a Pictet‐Spengler cyclization of an activated amino group derivatized in a carbamate form. The obtained compounds have been designed as potential serotonin analogs.