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Synthesis of N-methyl-4-pyridyl-1,2,3,4-tetrahydroisoquinolines via a pictet-spengler cyclisation

✍ Scribed by Laurence Prat; Vincent Levacher; Georges Dupas; Guy Quéguiner; Jean Bourguignon; Ronan Bureau; Cyril Daveu

Book ID: 102343295
Publisher: Journal of Heterocyclic Chemistry
Year: 2000
Tongue: English
Weight: 345 KB
Volume: 37
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570370417

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✦ Synopsis

Abstract

The synthesis of N‐methyl‐4‐pyridyl‐1,2,3,4‐tetrahydroisoquinolines (6a,b,c) was achieved via a Pictet‐Spengler cyclization of an activated amino group derivatized in a carbamate form. The obtained compounds have been designed as potential serotonin analogs.

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