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Synthesis of C-1 indol-3-yl substituted tetrahydroisoquinoline derivatives via a Pictet–Spengler approach

✍ Scribed by Rikard Larsson; Narda Blanco; Martin Johansson; Olov Sterner

Book ID
116909732
Publisher
Elsevier Science
Year
2012
Tongue
French
Weight
981 KB
Volume
53
Category
Article
ISSN
0040-4039

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## Abstract The synthesis of __N__‐methyl‐4‐pyridyl‐1,2,3,4‐tetrahydroisoquinolines **(6a,b,c)** was achieved __via__ a Pictet‐Spengler cyclization of an activated amino group derivatized in a carbamate form. The obtained compounds have been designed as potential serotonin analogs.

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