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Design and Synthesis of Highly Potent Benzodiazepine γ-Secretase Inhibitors: Preparation of (2 S ,3 R )-3-(3,4- Difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy- N -((3 S )-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1 H -benzo[ e ][1,4]- diazepin-3-yl)butyramide by Use of an Asymmetric Ireland−Claisen Rearrangement

✍ Scribed by Churcher, Ian; Williams, Susie; Kerrad, Sonia; Harrison, Timothy; Castro, José L.; Shearman, Mark S.; Lewis, Huw D.; Clarke, Earl E.; Wrigley, Jonathan D. J.; Beher, Dirk; Tang, Yui S.; Liu, Wensheng

Book ID: 120392578
Publisher: American Chemical Society
Year: 2003
Tongue: English
Weight: 101 KB
Volume: 46
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm034058a

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