Synthesis of some dehydrophenylalanine peptides
✍ Scribed by Breitholle, Edward G.; Stammer, Charles H.
- Book ID
- 121478030
- Publisher
- American Chemical Society
- Year
- 1976
- Tongue
- English
- Weight
- 822 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0022-3263
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📜 SIMILAR VOLUMES
## Abstract The removal of amino protecting groups from a series of twelve model Z‐^3)^ or TFA‐dipeptides of dehydroalanine and (Z)‐dehydrophenylalanine was investigated. During this deprotection, peptides with Δ Ala are prone to side reactions to a higher extent than those with Δ Phe. Therefore it
## Abstract Condensation of amides of Boc‐amino acids^3)^ with pyruvic acid leads to Boc‐dipeptides **1** – **3** of dehydroalanine and 1‐Boc‐5‐alkyl‐2‐methyl‐4‐oxo‐2‐imidazolidinecarboxylic acids **8** – **10**. The amides, however, do not condense with phenylpyruvic acid. Boc‐dipeptides of dehydr