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Conformations of dehydrophenylalanine containing peptides.

✍ Scribed by CHAUHAN, V.S. ;SHARMA, ASHWANI K. ;UMA, K. ;PAUL, P.K.C. ;BALARAM, P.


Book ID
115098575
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
430 KB
Volume
29
Category
Article
ISSN
0367-8377

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The conformation of an acyclic dehydrophenylalanine ( A'-Phe) containing hexapeptide, Boc-Phe-A'-Phe-Val-Phe-A'-Phe-Val-OMe, has been investigated in CDCl, and (CD,),SO by 270-MHz 'H-nmr. Studies of NH group solvent accessibility and observation of interresidue nuclear Overhauser effects (NOEs) sugg

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## Abstract Synthesis and conformational studies of a cecropin–melittin hybrid pentadecapeptide CA(1–7)MEL(2–9), and its three α, β‐dehydrophenylalanine (ΔPhe) containing analogs in water‐TFE mixtures are described. ΔPhe is placed at strategic positions in order to preserve the amphipathicity of th