Conformations of dehydrophenylalanine containing peptides.
✍ Scribed by CHAUHAN, V.S. ;SHARMA, ASHWANI K. ;UMA, K. ;PAUL, P.K.C. ;BALARAM, P.
- Book ID
- 115098575
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2009
- Tongue
- English
- Weight
- 430 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0367-8377
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The conformation of an acyclic dehydrophenylalanine ( A'-Phe) containing hexapeptide, Boc-Phe-A'-Phe-Val-Phe-A'-Phe-Val-OMe, has been investigated in CDCl, and (CD,),SO by 270-MHz 'H-nmr. Studies of NH group solvent accessibility and observation of interresidue nuclear Overhauser effects (NOEs) sugg
## Abstract Synthesis and conformational studies of a cecropin–melittin hybrid pentadecapeptide CA(1–7)MEL(2–9), and its three α, β‐dehydrophenylalanine (ΔPhe) containing analogs in water‐TFE mixtures are described. ΔPhe is placed at strategic positions in order to preserve the amphipathicity of th