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Synthesis of Peptides with α,β-Dehydroamino Acids, II. Synthesis oftert-Butyloxycarbonyldipeptides of Dehydroalanine and Dehydrophenylalanine

✍ Scribed by Makowski, Maciej ;Rzeszotarska, Barbara ;Kubica, Zbigniew ;Pietrzyńnski, Grzegorz

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
397 KB
Volume
1985
Category
Article
ISSN
0947-3440

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✦ Synopsis

Abstract

Condensation of amides of Boc‐amino acids^3)^ with pyruvic acid leads to Boc‐dipeptides 1 – 3 of dehydroalanine and 1‐Boc‐5‐alkyl‐2‐methyl‐4‐oxo‐2‐imidazolidinecarboxylic acids 8 – 10. The amides, however, do not condense with phenylpyruvic acid. Boc‐dipeptides of dehydroalanine (1 – 3) and dehydrophenylalanine (4 – 7) are synthesized using (Boc)~2~O and dehydrodipeptides with a free unmasked N‐terminal amino group.

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