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Synthesis of Peptides with α,β-Dehydroamino Acids, V. Coupling experiments with C-Terminal Dehydrophenylalanine and Dehydroalanine Residues

✍ Scribed by Makowski, Maciej ;Rzeszotarska, Barbara ;Kubica, Zbigniew ;Pietrzyński, Grzegorz ;Hetper, Jacek


Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
680 KB
Volume
1986
Category
Article
ISSN
0947-3440

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## Abstract The removal of amino protecting groups from a series of twelve model Z‐^3)^ or TFA‐dipeptides of dehydroalanine and (Z)‐dehydrophenylalanine was investigated. During this deprotection, peptides with Δ Ala are prone to side reactions to a higher extent than those with Δ Phe. Therefore it

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Condensation or Zand TFA-amino acid amides with 2-0x0acids. namely butanoic, 3-methylbutanoic, 4-methylpcntanoic, and (3RS)-3-methylpentanoic acid yields (in the presence of p toluenesulfonic acid as a catalyst) Z-and TFA-dipeptides with C-terminal AAbu" (1 -4). AVal (5-8), ALeu (9-11). and AIle (12