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Synthesis of peptides with α,β-dehydroamino acids, VI. Synthesis ofN-benzyloxycarbonyl andN-trifluoroacetyl dipeptides of α,β-dehydro-butyrine, -valine, -leucine, and -isoleucine

✍ Scribed by Smełka, Leszek ;Rzeszotarska, Barbara ;Pietrzyński, Grzegorz ;Kubica, Zbigniew

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 217 KB
Volume: 1988
Category: Article
ISSN: 0947-3440
DOI: 10.1002/jlac.198819880520

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✦ Synopsis

Condensation or Zand TFA-amino acid amides with 2-0x0acids. namely butanoic, 3-methylbutanoic, 4-methylpcntanoic, and (3RS)-3-methylpentanoic acid yields (in the presence of p toluenesulfonic acid as a catalyst) Z-and TFA-dipeptides with C-terminal AAbu" (1 -4). AVal (5-8), ALeu (9-11). and AIle (12 -15) (Table 1).

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Synthesis of Peptides with α,β-Dehydroam

Synthesis of Peptides with α,β-Dehydroamino Acids, I. Synthesis ofN-Benzyloxycarbonyl andN-Trifluoroacetyl Dipeptides of Dehydroalanine and Dehydrophenylalanine

✍ Makowski, Maciej ;Rzeszotarska, Barbara ;Kubica, Zbigniew ;Wieczorek, Piotr 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 475 KB

## Abstract Condensation of amides of __N__‐(benzyloxycarbonyl)‐ and __N__‐(trifluoroacetyl)amino acid with pyruvic and phenylpyruvic acid yields, in the presence of __p__‐toluenesulfonic acid as a catalyst, __N__‐(benzyloxycarbonyl)‐ and __N__‐(trifluoroacetyl)dehydro dipeptides with C‐terminal Δ