๐”– Bobbio Scriptorium
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Synthesis of some conformationally restricted analogs of fentanyl

โœ Scribed by Berger, Joel G.; Davidson, Fredric; Langford, Gordon E.


Book ID
115467163
Publisher
American Chemical Society
Year
1977
Tongue
English
Weight
397 KB
Volume
20
Category
Article
ISSN
0022-2623

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๐Ÿ“œ SIMILAR VOLUMES


Conformationally restricted leukotriene
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The stereocontrolled synthesis of conformationally restricted LTD4 analogs 2a. b is described. Epoxidation of enone 4 affords a 2.4:1 mixture of trans-epoxide 5 and cis-epoxide 9. Stereocontrolled elaboration of each epoxide to final product involves stereoselective Wittig olefination to Z-olefins 6

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The enantiomeric pair of conformationally-restricted nor-LTD4 analogs s and 11 have been synthesized stereoselectively from (g)-2-cyclohexen-l-01. Due to our continuing interest in the stereoselective syntheses of conformationallyrestricted LTDl analogsr, we were attracted by recent reports' that 2-