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Conformationally restricted leukotriene antagonists. Asymmetric synthesis of some nor-leukotriene D4 analogs

โœ Scribed by Jeffrey S Sabol; Robert J Cregge

Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
167 KB
Volume
30
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

The enantiomeric pair of conformationally-restricted nor-LTD4 analogs s and 11 have been synthesized stereoselectively from (g)-2-cyclohexen-l-01. Due to our continuing interest in the stereoselective syntheses of conformationallyrestricted LTDl analogsr, we were attracted by recent reports' that 2-nor-leukotriene analogs such as SKF 101132 possess significant LTDl antagonist activity. The correlation observed

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