๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Conformationally restricted leukotriene antagonists. Asymmetric synthesis of a nor-leokotriene D4 analog. II.

โœ Scribed by Jeffrey S Sabol; Robert J Cregge


Publisher
Elsevier Science
Year
1990
Tongue
French
Weight
229 KB
Volume
31
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.


๐Ÿ“œ SIMILAR VOLUMES


Conformationally restricted leukotriene
โœ Jeffrey S Sabol; Robert J Cregge ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 167 KB

The enantiomeric pair of conformationally-restricted nor-LTD4 analogs s and 11 have been synthesized stereoselectively from (g)-2-cyclohexen-l-01. Due to our continuing interest in the stereoselective syntheses of conformationallyrestricted LTDl analogsr, we were attracted by recent reports' that 2-

Conformationally restricted leukotriene
โœ Jeffrey S. Sabol; Philip M. Weintraub; Thomas H. Gieske; Robert J. Cregge ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 385 KB

The stereocontrolled synthesis of conformationally restricted LTD4 analogs 2a. b is described. Epoxidation of enone 4 affords a 2.4:1 mixture of trans-epoxide 5 and cis-epoxide 9. Stereocontrolled elaboration of each epoxide to final product involves stereoselective Wittig olefination to Z-olefins 6

Conformationally restricted leukotriene
โœ Jeffrey S. Sabol; Robert J. Cregge ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 142 KB

Lewis acid catalyzed allylation of diacetyl-D-xylal 2 is stereoselectlve for ~-C-glycoside 2b, a result used in the syntheses of pyrans 8a, b, from D-xylose. Vhile pursuing approaches to the stereocontrolled syntheses of conformationally-restrlcted LTD 4 receptor antagonists, we became aware of a hi