3H-Sch 47949, racemic 3H-Sch 48461, was prepared at a specific activity of 40 mCi/mmole by Pt catalysed exchange with tritiated water. 3H-Sch 48461 was prepared at a specific activity of 64.6 Ci/mmole by a Pd/C catalysed reduction of an olefinic intermediate. 14C-Sch 48461 was prepared in 8 steps fr
Synthesis of some [3H]- and [14C]labelled antineoplastic
β Scribed by J.A. Kepler; B.D. Berrang; I.D. Correa; C.J. LeFevre; G.F. Taylor
- Publisher
- Elsevier Science
- Year
- 1988
- Weight
- 65 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0883-2889
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## Abstract [^3^H]SCH 211803, at a specific activity of 1.56 Ci/mmol, was prepared by direct exchange with tritiated water and platinum metal. [^2^H~4~]SCH 211803 was prepared from [^2^H]formaldehyde in a seven step synthesis in 10% yield. [^14^C]SCH 211803 was prepared from __N__βbenzylβ4βhydroxy[