๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Synthesis of SMP-797: A New Potent ACAT Inhibitor.

โœ Scribed by Hitoshi Ban; Masami Muraoka; Naohito Ohashi

Publisher
John Wiley and Sons
Year
2006
Weight
26 KB
Volume
37
Category
Article
ISSN
0931-7597

No coin nor oath required. For personal study only.

โœฆ Synopsis

Abstract

For Abstract see ChemInform Abstract in Full Text.

๐Ÿ“œ SIMILAR VOLUMES

Synthesis of a new series of potent inhi
Synthesis of a new series of potent inhibitors of thromboxane A2 biosynthesis
โœ E.J. Corey; Stephen G. Pyne; Andrew I. Schafer ๐Ÿ“‚ Article ๐Ÿ“… 1983 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 206 KB

The pyridino prostanoids 2, 12 and lfl have been synthesized (in racemic form) and have been found to be effective inhibitors of the biosynthesis of thromboxane A2 in human platelets QC,, l-3 PM).

Inhibitors of acyl-CoA: Cholesterol O-ac
Inhibitors of acyl-CoA: Cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 13. Design, synthesis and biological evaluation of tetrazole anilides as potent inhibitors of ACAT in vitro and hypocholesterolemic agents in vivo
โœ Patrick M. O'Brien; Drago R. Sliskovic; Adele Bernabei; Timothy Hurley; Maureen ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 274 KB

The syntheses and biological activities for anilides derived from 2-phenyl-2-(dodecyl-2H-tetrazol-5-yl)acetic acid are described. Evidence is provided that one of these compounds, (+)-8b, stereoselectively inhibits ACAT in vitro and possesses superior efficacy in vivo compared to (-)-8b or the racem