Synthesis and structure-activity relationships of new ACAT inhibitors
✍ Scribed by JY Nioche; J Decerprit; D Festal
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 732 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0223-5234
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📜 SIMILAR VOLUMES
To examine the effects of bioisosteric replacement on the biological activity of our previously disclosed disubstituted urea inhibitors of the enzyme acyl-CoA:cholesterol acyltransferase (ACAT), we prepared a series of N'-substituted and N',N'-disubstituted glycine anilides. These compounds were tes
## Abstract For Abstract see ChemInform Abstract in Full Text.
Autotaxin (ATX) is a secreted soluble enzyme that generates lysophosphatidic acid (LPA) through its lysophospholipase D activity. Because of LPA's role in neoplastic diseases, ATX is an attractive therapeutic target due to its involvement in LPA biosynthesis. Here we describe the SAR of ATX inhibito