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Synthesis of SCH 42427 labelled with 14C in two different positions

✍ Scribed by D. Hesk; C. Bowlen; T. Duelfer; D. Koharski; P. McNamara; S. Saluja

Publisher
John Wiley and Sons
Year
1992
Tongue
French
Weight
484 KB
Volume
31
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

[^14^C]‐Sch 42427 was synthesized by two different methods, resulting in incorporation of the label in different parts of the molecule. In the first synthesis [benzyl‐α‐^14^C]‐Sch 42427 was synthesized in overall 1.7% yield via a 6 step procedure, using [^14^C]‐trimethyl sulphoxonium iodide as the source of label. The second synthesis gave rise to [SO~2~‐^14^CH~3~]‐Sch 42427, which was prepared via a 2 step procedure from [^14^C]‐sodium thiomethoxide. Radiochemical purities were greater than 99% for both batches, and analysis by chiral hplc failed to detect any of the undesired S,S enantiomer.

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