Synthesis of S-[3H]-DO-710, a benzamide ligand of the D2-dopamine receptor and of S-[3H]-azidosulpride, its photoactivable analog

✍ Scribed by D. Rognan; A. Mann; P. Hamdi; C. C. Wermuth; P. Sokoloff; J. J. Schwartz; J. Roy; J. J. Morgat

• Book ID: 102375725
• Publisher: John Wiley and Sons
• Year: 1987
• Tongue: French
• Weight: 412 KB
• Volume: 24
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580241113

✦ Synopsis

The p r e p a r a t i o n o f t h e t r i t i u m l a b e l l e d benzamides, S-[ 3 H 1-00-710 3 and S-[ H I -a z i d o s u l p r i d e i s reported. The synthesis i n v o l v e s enant i o s e l e c t i v e p r e p a r a t i o n o f t h e p y r r o l i d i n y l moiety, r e d u c t i v e t r i t i a t i o n o f an a l l y l i c precursor and conversion o f an amino, t o an azido f u n c t i o n .