## Abstract A new dopamine D2โlike receptor ligand, (__R,S__)__trans__โ5โhydroxyโ2โ[NโnโpropylโNโ(3โฒโiodoโ2โฒโpropenyl)amino]tetralin ((__R,S)trans__โ5โOHโPIPAT, 3), based on high affinity dopamine receptor agonist 5โhydroxyโ2โ[N,Nโ(diโnโpropyl)โ2โamino]tetralin (5โOHโDPAT, 1). was prepared. The syn
Synthesis and optical resolution of (R)- and (S)-trans-7-hydroxy-2-[N-propyl-N-(3'-iodo-2'-propenyl)amino]tetralin: a new D3 dopamine receptor ligand
โ Scribed by Chumpradit, Sumalee; Kung, Mei Ping; Kung, Hank F.
- Book ID
- 126145692
- Publisher
- American Chemical Society
- Year
- 1993
- Tongue
- English
- Weight
- 658 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0022-2623
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
R, S)trans-8-Hydroxy-2-[N-n-propy1-N-(3'-iodo-2'-propeny1)amino]tetraralin 7, a new radioiodinated ligand based on 8-OH-DPAT, was reported as a potential ligand for 5-HTlA receptors. The optically active (+)-(R)-and (-)-(S)-7 were prepared to investigate the stereoselectivity of (R, 3-7. Racemic int
The present study was designed to characterize the dopamine D 3 receptor agonist R()-7-hydroxy-N,N-di-n-propyl-2-aminotetralin (R()-7-OH-DPAT)-induced changes in locomotor activity in mice. Although R()-7-OH-DPAT (0 . 01ยฑ10 mg/kg) produced a signiยฎcant decrease in horizontal and vertical motility wi