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Synthesis of (R,S)-trans-8-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'-propenyl)amino]tetralin (trans 8-OH-PIPAT): a new 5-HT1A receptor ligand

✍ Scribed by Zhuang, Zhi Ping; Kung, Mei Ping; Kung, Hank F.

Book ID
126162416
Publisher
American Chemical Society
Year
1993
Tongue
English
Weight
715 KB
Volume
36
Category
Article
ISSN
0022-2623

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## Abstract The title compounds were synthesised in 7 steps from 1,7‐dihydroxynaphthalene as follows: 1,7‐dihydroxynaphthalene was methylated and subjected to a Birch reduction to yield 8‐methoxy‐2‐tetralone. Reductive amination with sodium cyanoboro[^3^H]hydride and n‐propylamine gave 8‐methoxy‐2‐