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Synthesis and in Vitro Pharmacology of a Series of New Chiral Histamine H 3 -Receptor Ligands: 2-( R and S )-Amino-3-(1 H -imidazol-4(5)-yl)propyl Ether Derivatives

✍ Scribed by Kovalainen, Jari T.; Christiaans, Johannes A. M.; Kotisaari, Sanna; Laitinen, Jarmo T.; Männistö, Pekka T.; Tuomisto, Leena; Gynther, Jukka


Book ID
126837958
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
253 KB
Volume
42
Category
Article
ISSN
0022-2623

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Synthesis, spectroscopic characterizatio
✍ Nevin Süleymanoğlu; Reşat Ustabaş; Yelda Bingöl Alpaslan; Yasemin Ünver; Mustafa 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 877 KB

a b s t r a c t 4-(3-(1H-imidazol-1-yl)propyl)-(thiophen-2-ylmethyl)-1H-1,2,4-triazol-5(4H)-one (IPTT), C 13 H 15 N 5 OS, was synthesized and characterized by 13 C NMR, 1 H NMR, IR and single-crystal X-ray diffraction. The structure of IPTT is stabilized by three intermolecular hydrogen bonds and by