Characterization of the Binding Site of the Histamine H 3 Receptor. 1. Various Approaches to the Synthesis of 2-(1 H -Imidazol-4-yl)cyclopropylamine and Histaminergic Activity of (1 R ,2 R )- and (1 S ,2 S )-2-(1 H -Imidazol-4-yl)- cyclopropylamine
✍ Scribed by De Esch, Iwan J. P.; Vollinga, Roeland C.; Goubitz, Kees; Schenk, Henk; Appelberg, Ulf; Hacksell, Uli; Lemstra, Sylvia; Zuiderveld, Obbe P.; Hoffmann, Marcel; Leurs, Rob; Menge, Wiro M. P. B.; Timmerman, Henk
- Book ID
- 121881831
- Publisher
- American Chemical Society
- Year
- 1999
- Tongue
- English
- Weight
- 178 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0022-2623
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a b s t r a c t 4-(3-(1H-imidazol-1-yl)propyl)-(thiophen-2-ylmethyl)-1H-1,2,4-triazol-5(4H)-one (IPTT), C 13 H 15 N 5 OS, was synthesized and characterized by 13 C NMR, 1 H NMR, IR and single-crystal X-ray diffraction. The structure of IPTT is stabilized by three intermolecular hydrogen bonds and by
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