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Synthesis of [3H] aminocyclopropane carboxylic acid (ACC) as a ligand for the glycine b receptor

โœ Scribed by Michael S. Dappen; Charles S. Markos; Christopher J. Gresk; Alex A. Cordi


Book ID
102373798
Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
221 KB
Volume
28
Category
Article
ISSN
0022-2135

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โœฆ Synopsis


Abstract

The synthesis of [^3^H] Aminocyclopropane carboxylic acid (ACC, 1) at high specific activity and high purity is described. The compound has been developed as a specific ligand for the Glycineโ€B binding site.


๐Ÿ“œ SIMILAR VOLUMES


One-step preparation of [2,3-3H]1-aminoc
โœ A. H. Lewin; P. B. Lamb; P. Popik; P. Skolnick ๐Ÿ“‚ Article ๐Ÿ“… 1994 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 267 KB

## Abstract Catalytic hydrogenation of 1โ€aminocyclopropenecarboxylic acid under tritium gas afforded [2,3โ€^3^H]1โ€aminocyclopropanecarboxylic acid with specific activity 26 Ci/mmol, determined by a combination of ^1^H and ^3^H NMR. Pilot radioligand binding assays indicate this compound will be a us