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One-step preparation of [2,3-3H]1-aminocyclopropanecarboxylic acid: A useful ligand for strychnine-insensitive glycine receptors

✍ Scribed by A. H. Lewin; P. B. Lamb; P. Popik; P. Skolnick

Publisher: John Wiley and Sons
Year: 1994
Tongue: French
Weight: 267 KB
Volume: 34
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580341109

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✦ Synopsis

Abstract

Catalytic hydrogenation of 1‐aminocyclopropenecarboxylic acid under tritium gas afforded [2,3‐^3^H]1‐aminocyclopropanecarboxylic acid with specific activity 26 Ci/mmol, determined by a combination of ^1^H and ^3^H NMR. Pilot radioligand binding assays indicate this compound will be a useful probe for the NMDA receptor‐associated strychnine‐insensitive glycine receptor.

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