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Asymmetric Synthesis with 6-tert-Butyl-5-methoxy-6-methyl-3,6-dihydro-2H-1,4-oxazin-2-one as a New Chiral Glycine Equivalent: Preparation of Enantiomerically Pure α-Tertiary and α-Quaternary α-Amino Acids.

✍ Scribed by Claus-Juergen Koch; Sona Simonyiova; Joerg Pabel; Annerose Kaertner; Kurt Polborn; Klaus Theodor Wanner


Publisher
John Wiley and Sons
Year
2003
Weight
349 KB
Volume
34
Category
Article
ISSN
0931-7597

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Asymmetric Synthesis Employing a Chiral
✍ Oliver Achatz; Andrea Grandl; Klaus Theodor Wanner 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 423 KB 👁 1 views

A new asymmetric synthesis of disubstituted α-amino acids From the major diastereomers 17c-d the corresponding αamino acids 19c-d are obtained enantiomerically pure upon is presented. This synthesis is based on the chiral 5-methoxy-1,4-oxazin-2-one derivative 5 relying on the α-hydroxy acid hydroly