Synthesis of Regioselectively Deuterated Cyclopropanes
β Scribed by Duffault, Jean-Marc; Hanoteau, Pascal; Parrilla, Alfredo; Einhorn, Jacques
- Book ID
- 120326180
- Publisher
- Taylor and Francis Group
- Year
- 1996
- Tongue
- English
- Weight
- 366 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0039-7911
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π SIMILAR VOLUMES
1 -Methyl-4-phenyl-2-pyridone has been used as starting material for the efficient and regioselective synthesis of deuterated analogues of the neurotoxin 1 -methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP). MPTP-2,242, MPTP-6,6-& and MPTP-2,2,6,6-d4 were obtained in good yield through a combination
Iodonium ylides of methyl 3-oxo-trans,trans-6,8-tetradecadienoate (1) and diprotected methyl 3,5-di(tbutyldimethyl-silyloxy)-2,6,8-tetradecalrieneoate (5) undergo regio-and stereoselective inwamolecular cyclopropanation with Cu(I)CI catalysis to form key bicyclo[3.1.0] intermediates for prostaglandi