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Synthesis of regioselectively deuterated hydroxy conjugated dienes

โœ Scribed by Jean-Marc Duffault; Jacques Einhorn; Alexandre Alexakis


Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
161 KB
Volume
36
Category
Article
ISSN
0040-4039

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Regioselective synthesis of deuterated a
โœ Stรฉphane Mabic; Neal Castagnoli Jr. ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 312 KB ๐Ÿ‘ 1 views

1 -Methyl-4-phenyl-2-pyridone has been used as starting material for the efficient and regioselective synthesis of deuterated analogues of the neurotoxin 1 -methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP). MPTP-2,242, MPTP-6,6-& and MPTP-2,2,6,6-d4 were obtained in good yield through a combination